The Body Becomes the Cure: Myeloid's mRNA CARs Redefine Cancer Fight!

A New Dawn in Cancer Warfare: Myeloid Therapeutics stuns ASCO 2025 with first-ever human data from in vivo mRNA CAR therapies, directly reprogramming immune cells inside the body.
Shattering Old Limits: These revolutionary treatments, MT-302 and MT-303, bypass complex lab work, offering a potent, "off-the-shelf" attack against advanced solid tumors.
Tumor Strongholds Breached: Early findings reveal these mRNA-supercharged myeloid cells can penetrate and reshape hostile tumor environments, heralding a paradigm shift in immuno-oncology.

The battle against cancer has just witnessed a seismic shift. At the prestigious 2025 ASCO Annual Meeting, Myeloid Therapeutics tore back the curtain on a future once confined to science fiction: the first-in-human data from in vivo mRNA CAR therapies. This isn't just an update; it's a declaration that the very rules of engagement against cancer are being rewritten^{1, 6}.

Imagine therapies that transform your own immune cells into precision cancer assassins directly within your body, eliminating the complex, time-consuming ex vivo cell manipulation of old. Myeloid's pioneering treatments, MT-302 targeting TROP2-expressing tumors and MT-303 aimed at aggressive GPC3+ cancers like hepatocellular carcinoma, are making this a reality^{2, 5, 4, 7}. "We are pushing beyond the limits of traditional CAR therapies," declared Myeloid's CEO, heralding a move towards potent, tumor-specific immune activation without the burdens of conventional cell therapies.

These revolutionary therapies, delivered intravenously using advanced lipid nanoparticles, are showing that CAR-programmed myeloid cells can successfully penetrate stubborn solid tumors and reshape their hostile microenvironments¹. As Myeloid's Chief Medical Officer stated, these results "could ultimately change how solid tumors are treated," offering patients a more accessible, potentially more tolerable, and highly targeted lifeline. The era of directly engineering the immune response inside the patient has dawned.

The Body Becomes the Cure: Myeloid's mRNA CARs Redefine Cancer Fight!

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