Four Years of Defiance: Patient Thrives After Revolutionary Glioblastoma Therapy

A patient with deadly glioblastoma, a grade 4 IDH-mutant glioma, has defied the odds, achieving an incredible 4 years in remission.
IN8bio's innovative INB-200 therapy, using genetically modified gamma-delta T cells, demonstrates groundbreaking potential, far exceeding standard care outcomes.
This milestone offers profound hope and a "life changing clinical impact" in the relentless fight against one of cancer's most aggressive forms.

In a stunning development that pierces the grim prognosis often associated with glioblastoma (GBM), IN8bio (Nasdaq: INAB) announced that Patient 009 from its Phase 1 trial of INB-200 has reached an extraordinary 4-year remission milestone^{1, 3, 6}. This patient, diagnosed with a grade 4, IDH-mutant glioma, is not just surviving but thriving—having returned to work and enjoying a good quality of life, a testament to the therapy's profound impact.

For over two decades, the standard of care for newly diagnosed GBM has offered a bleak overall survival of merely 14-16 months. INB-200, the first genetically modified gamma-delta T cell therapy evaluated in GBM, is shattering these limitations. Data from the trial recently presented at ASCO revealed that repeated doses of INB-200 achieved an extended median Progression-Free Survival (mPFS) of 16.1 months, more than double the 6.9 months typically seen with standard protocols⁷.

Dr. Burt Nabors, Principal Investigator, hailed the 4-year survival as a "significant achievement demonstrating the potential activity of gamma-delta T cells." William Ho, CEO of IN8bio, emphasized, "This type of long-term survival and life changing clinical impact is exactly what we strive to achieve." With a favorable safety profile^{4, 7}, INB-200 is not just a statistic; it's a beacon of hope, potentially rewriting the future for those battling this most "aggressive, difficult-to-treat and deadly" cancer⁵.

Four Years of Defiance: Patient Thrives After Revolutionary Glioblastoma Therapy

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