A New Dawn in the Battle Against Alcoholism

Historic First: The very first patient has been dosed with CMND-100, a groundbreaking psychedelic-derived therapy for Alcohol Use Disorder (AUD)^{1, 5}.
A Revolutionary Approach: The oral drug, a neuroplastogen compound, aims to target the neurological roots of addiction, potentially reducing cravings and consumption^{1, 2}.
Elite Clinical Trials: The multinational study is underway at world-leading institutions, including Yale School of Medicine and Johns Hopkins University^{1, 6}.

The fight against Alcohol Use Disorder (AUD) has just witnessed a seismic shift. In a landmark moment for medicine, Clearmind Medicine has administered the first-ever human dose of CMND-100, its revolutionary MEAI-based oral treatment, igniting a new beacon of hope for the hundreds of millions battling alcoholism worldwide^{1, 3, 4}.

This is no ordinary trial. Conducted at the most prestigious clinical sites on the planet—from Yale and Johns Hopkins in the U.S. to leading medical centers in Israel—this Phase I/IIa study marks the dawn of a new era^{1, 5}. The mission: to test a powerful neuroplastogen compound designed not just to manage symptoms, but to potentially remodel the brain's pathways away from addiction¹.

For the first time, this innovative, psychedelic-derived science is being tested in a controlled clinical setting, moving from the laboratory to the front lines of a global health crisis. "Dosing the first participant...marks a landmark achievement," stated Dr. Adi Zuloff-Shani, Ph.D., CEO of Clearmind Medicine, calling it "new hope for the massive, underserved community suffering from alcoholism"¹. This historic first step aims to evaluate the drug's safety and seek early signals of its power to break the chains of alcohol dependence, paving the way for what could be a life-altering therapy^{1, 2}.

For further information visit: www.clearmindmedicine.com or contact: Investor Relations Telephone: (604) 260-1566 Email: [email protected]

A New Dawn in the Battle Against Alcoholism

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